Synthroid is indicated as a replacement therapy in primary (thyroidal), secondary (pituitary), and tertiary (hypothalamic) congenital or acquired hypothyroidism. Adverse reactions associated with SYNTHROID therapy are primarily those of hyperthyroidism due to therapeutic overdosage: arrhythmias, myocardial infarction. Hashimoto's thyroiditis, multinodular goiter and, as adjunctive therapy in the . SYNTHROID should not be used as a primary or adjunctive therapy in a weight.
Table 1. Ratio in Thyroglobulin. Pseudotumor cerebri and slipped capital femoral epiphysis have been reported in children receiving levothyroxine therapy. Congenital Hypothyroidism [See Dosage and Administration 2. Synthroid levothyroxine sodium, USP tablets are supplied as follows:. Subscribe to Drugs. Administer thyroid hormone products formulated for intravenous synthrooid to treat myxedema coma. Furosemide competes for T4-binding sites on TBG, prealbumin, and albumin, so that a single high dose can acutely lower the total T4 level. SYNTHROID should not be used to treat noncancerous growths or enlargement of the thyroid in patients with normal iodine levels, or in cases of temporary hypothyroidism caused by inflammation of the thyroid gland thyroiditis. The dose of SYNTHROID for hypothyroidism or pituitary TSH suppression depends on a variety of synhtroid including: the patient's age, body weight, cardiovascular status, concomitant medical conditions including pregnancyconcomitant medications, co-administered food and the specific nature of the condition being treated [see Dosage and Administration 2. Use of oral thyroid hormone diflucan 200 mg candida
products is not recommended to treat myxedema coma. In children with severe or prolonged hypothyroidism, catch-up growth may not be adequate to normalize adult height. Generic Name: levothyroxine sodium Dosage Form: tablet. In adult synthroid therapy
with primary hypothyroidism, monitor serum TSH levels after an interval of 6 to 8 weeks after any change in dose.
Synthroid therapy - know
Monitor TSH and total or free-T4 in children as follows: 2 and 4 weeks after the initiation of treatment, 2 weeks after any change in dosage, and then every 3 to 12 months thereafter following dose stabilization until growth is completed. Rifampin has been shown to accelerate the metabolism of levothyroxine. Triiodothyronine T3 and L-thyroxine T4 diffuse into the cell nucleus and bind to thyroid receptor proteins attached to DNA. In children in whom a diagnosis of permanent hypothyroidism has not been established, discontinue SYNTHROID administration for a trial period, but only after the child is at least 3 years of age. Potential impact: Stimulation of hepatic microsomal drug-metabolizing enzyme activity may cause increased hepatic degradation of levothyroxine, resulting in increased SYNTHROID requirements. Diabetes; monitor glucose control. An inadequate response to daily doses of greater than mcg per day is rare and may indicate poor compliance, malabsorption, drug interactions, or a combination of these factors. Instruct patients to notify their healthcare provider if they are taking any other medications, including prescription and over-the-counter preparations. They include the following: General: fatigue, increased appetite, weight loss, heat intolerance, fever, excessive sweating Central nervous system: headache, hyperactivity, nervousness, anxiety, irritability, emotional lability, insomnia Musculoskeletal: tremors, synthroix weakness, muscle spasm Cardiovascular: palpitations, tachycardia, arrhythmias, increased pulse and blood pressure, heart failure, angina, myocardial infarction, cardiac arrest Respiratory: dyspnea Gastrointestinal: diarrhea, vomiting, abdominal cramps, elevations in liver function tests Dermatologic: hair loss, flushing, rash Endocrine: decreased bone mineral density Reproductive: menstrual irregularities, impaired fertility Seizures have been reported rarely with the institution of levothyroxine therapy. Generic Availability: YES. Not indicated for treatment of hypothyroidism during the recovery phase of subacute thyroiditis. Levothyroxine is approved for use as a replacement therapy for hypothyroidism. Pseudotumor cerebri and slipped capital femoral epiphysis have been reported in children receiving levothyroxine therapy. In patients with congenital hypothyroidism, assess the adequacy of replacement therapy synthroid therapy
measuring both serum TSH and total or free-T4. Subscribe to Drugs. Dietary fiber decreases bioavailability of T4. Thyroid hormones are also metabolized via conjugation with glucuronides and sulfates and excreted directly into the bile and gut where they undergo synthorid recirculation. Beta-adrenergic antagonists e.