Synthroid interactions with grapefruit11.02.2019
The grapefruit diet is a popular weight loss approach that may accelerate weight Using this weight loss approach can pose dangerous drug interactions Many thyroid drugs, including levothyroxine, rely on CYP3A4 for. Q. Does grapefruit juice affect levothyroxine effectiveness? a professor emeritus of clinical pharmacology who first described the interaction. Grapefruit juice may slightly delay the absorption of levothyroxine, but it seems to have only a Keywords: food-drug interaction, grapefruit juice, levothyroxine. Choose a degree. Food and Drug Administration. The problem, of course, is that diet plans are never as simple as proponents claim. While there are many variations of the diet, they are all ultimately based on the belief that grapefruit contains "fat-burning enzymes" or witj "speeds up" the body's natural metabolism. If CYP3A4 is inhibited due to grapefruit consumption, the bioavailability of a thyroid drug the amount that enters the bloodstream can be significantly reduced, undermining the benefits of therapy. Accessed Oct. Inhibition of Metabolism. Hospital Pharmacy. Lilja, et al. Subscribe to Drugs. Find out now. In the s and early s, grapefruit was embraced anew in so-called "day, pounds-off" diets for which the fruit was to be eaten with every meal and usually without the need for exercise or any other dietary interactilns. Department of Agriculture, grapefruit is the second leading citrus fruit consumed per capita in the United States. David Bailey, a professor emeritus of clinical pharmacology who first described the interaction and periodically updates a link of affected drugs maintained by the Canadian Pharmacists Association. All rights reserved. Answer From Katherine Zeratsky, R.