Mechanism of action for diflucan

20.01.2019 1 By Yolabar

mechanism of action for diflucan

Fluconazole (FLZ) is a potent antifungal agent, and various classes of drug delivery Although the exact mechanism of action of fluconazole is not yet known. Fluconazole is a fluorine-substituted, bis-triazole antifungal agent. Its mechanism of action, like that of other azoles, involves interruption of the conversion of. Parracoccidioides brasiliensis, Sporothrix schenkii, Penicillium marneffei ( variable activity). Mechanism of Action: Inhibits fungal cytochrome P 3A dependent. mechanism of action for diflucan

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Archived from the original on 8 April Fluconazole may decrease the excretion rate of Isosulfan blue which could result in a higher serum level. The risk or severity of hypoglycemia can be increased when Pentamidine is combined with Fluconazole. It is recommended to avoid this combination when hydrocodone is being used for cough. Amphotericin B: Moderate Theoretically, azole antifungals could interfere with the action of amphotericin B by depleting polyene binding sites. Meclofenamic acid may decrease the excretion rate of Fluconazole which could result in a higher serum level. In addition, fluconazole has been reported to increase the effects of amitriptyline, perhaps through inhibition of the hepatic microsomal CYP2C19 or CYP3A4 isoenzymes. Fingolimod has not been studied in patients treated with drugs that prolong the QT high dose of synthroid, mechanism of action for diflucan drugs that prolong the QT interval have been associated with cases of TdP in patients with bradycardia. Nifenazone may decrease the excretion rate of Fluconazole which could result in a higher serum level. Fluconazole may decrease the excretion rate of Galantamine which could result in a higher serum level. Alminoprofen may decrease the excretion rate of Fluconazole which could result in a higher serum level. The risk or severity of hyperkalemia can be increased when Fluconazole is combined with Gabapentin. Both fluconazole and crizotinib have been associated with QT prolongation; fluconazole has also been associated with rare cases of torsade de pointes TdP. Diclofenamide may increase the excretion rate of Fluconazole which could result in a lower serum level and potentially a reduction in efficacy. Dosage reduction is advised for patients with impaired renal function. The risk or severity of QTc prolongation can be increased when Fluconazole is combined with Escitalopram. Bendazac may decrease the excretion rate of Fluconazole grapefruit synthroid drug could result in a higher serum level. Glasdegib is a CYP3A4 substrate that may result in QT prolongation and ventricular arrhythmias including ventricular fibrillation and ventricular tachycardia. The risk of developing myopathy during therapy with atorvastatin is increased if coadministered with fluconazole, a CYP3A4 inhibitor. Inhibition of these isoenzymes may increase the plasma concentration of bosentan. Ventricular arrhythmias and torsade de pointes TdP have been reported with the use of fo. The risk of developing myopathy during therapy with atorvastatin is increased if coadministered with fluconazole, a CYP3A4 inhibitor. The risk or severity of QTc prolongation can be increased when Fluconazole is combined with Deutetrabenazine. The risk or severity of QTc prolongation can be increased when Fluconazole is combined with Histrelin. Follow with mg IV once daily for suppressive therapy. The risk or severity of hypoglycemia can be increased when Lixisenatide is combined with Fluconazole. In addition, measure serum creatinine and serum potassium within 3 to 7 days of initiating a CYP3A4 inhibitor and periodically thereafter. The risk or severity of hyperkalemia can be increased when Fluconazole is combined with Perindopril. Estradiol; Norgestimate: Minor As fluconazole inhibits CYP3A4 activity, serum estrogen concentrations and estrogenic-related side effects e. However, because armodafinil is itself an inducer of the CYP3A4 isoenzyme, drug diflcuan due to CYP3A4 inhibition by other medications may be complex and difficult to predict. Fluconazole may decrease the excretion rate difluucan Invert sugar which could result in a higher serum level. Fluconazole may decrease the excretion rate mechahism Cisplatin which could result in a higher serum level. Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir: Major Avoid concurrent administration of fluconazole with dasabuvir; ombitasvir; paritaprevir; ritonavir due to an increased risk of QT prolongation. Ceforanide may decrease the excretion rate of Fluconazole which could result in a higher serum level. Acetaminophen; Oxycodone: Moderate Consider a reduced dose of oxycodone with frequent monitoring for respiratory depression acgion sedation if concurrent use of synthroid brand name cost is necessary.